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Magazines  >>  GPCR Pathways  >>  Issue No. 5

GPCR Pathways

Issue No. 5

Regulatory Aspects of mGluRs
Metabotropic glutamate receptors (mGluRs) are functionally important for inducing long term potentiation (LTP) and long term depression (LTD). They are essential for synaptic transmission, neuronal development, neuroprotection and cognition. Alomone Labs offers antibodies targeting extracellular epitopes of mGluRs. Such antibodies enable to detect mGluRs in living cells, and to monitor cell surface receptors. Also available are fluorescent labeled antibodies which enable colocalization studies involving mGluRs. In this brief report, we summarize papers elegantly using Alomone Labs mGluR antibodies.
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Melanocortin Receptors in the Kidney and Nervous System
The five melanocortin receptors are members of the seven-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Melanocortins, the ligands of the receptors are a group of structurally similar peptides consisting of α-, β- and γ-melanocyte stimulating hormone (α, β, γ-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translational processing of a common precursor peptide, proopiomelanocortin (POMC).
One of the most significant characteristics of the melanocortin signaling system is the presence of two endogenous antagonists, agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP). All five melanocortin receptors bind their agonists and their endogenous antagonists with different affinities. In this short article we report the use of Alomone Labs products in melanocortin-related research.
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Cannabinoid Signaling in the Nervous System
Cannabinoids have been used in Eastern medicine for many years as pain relievers. Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 Receptor or CB1R) and cannabinoid receptor 2 (CB2 Receptor or CB2R). The cannabinoid receptors can be distinguished by their amino acid sequences, signaling mechanisms, and tissue distributions. Both receptors belong to the G-protein-coupled receptor (GPCR) superfamily. Alomone Labs is pleased to offer antibodies to both receptors. This paper cites the use of these antibodies in various scientific papers.
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In Focus: Formyl peptide Receptors
Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). 
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