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Magazines  >>  Modulator  >>  Issue No. 26

Modulator

Issue No. 26


Setting the Pace with NaV1.5 Channels
SCN5A is the gene encoding NaV1.5 voltage-gated Na+ channels. These membrane proteins are responsible for the initiation and propogation of the excitable cell action potential in the heart. They have been extensively studied over the years due to their critical importance in regulation of cardiac pulsing, and are the prime target for several important antiarrhythmic drugs. This article briefly reviews the contribution of Alomone Labs products to the understanding of NaV1.5 role and function at the cellular and physiological levels.
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Ion Channels and Pain
Pain perception becomes a burden and ceases to be physiologically beneficial when the threat causing the pain is gone and the pain sensations remain. Such pathological, chronic conditions appear due to improper functionality of the ion channels responsible for sensory transmission. This short piece aims at reviewing progress in nociception using Alomone Labs products.
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T-Type Ca2+ Channels
T-type Ca2+ channels are at the heart of numerous research topics such as pain and epilepsy. This paper aims at describing various aspects of CaV3 regulation, their role in LTP, cell proliferation, exocytosis and neurotransmitter release and finally, their role in excitation-contraction in afferent arterioles using Alomone Labs products.
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In Focus: Labeled α-Bungarotoxin
α-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs) with an IC50 of 3.5 x 10-10 M, thereby prevents the depolarizing action on postsynaptic membranes and blocks neuromuscular transmission.
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In Focus: NCX Exchangers
NCX-1 is one of three Na+/Ca2+ exchangers (NCX-1, NCX-2, NCX-3) leading to one Ca2+ movement across the plasma membrane in exchange of three Na+ influx. However, the transporter can reverse the direction of the transport if the concentrations of Na+ and Ca2+ change. The transporter has nine transmembrane domains and intracellular N- and C-terminals.
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