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Ion Channels >> Intracellular Ion Channels >> Ryanodine Receptor Channels >> Antibodies

Anti-Ryanodine Receptor 2

Cardiac Ryanodine Receptor, RyR2
  • Antigen included
    Antigen included
  • Shipped at room temp.
    Shipped at room temp.
  • QC tested
    QC tested
  • Cat #: ARR-002
  • Size: 25 µl, 50 µl, 0.2 ml
  • Source: Rabbit
  • Type:  Polyclonal
Application: IC, IH, WB
Reactivity: H, M, R
May also work in: IFC, IP
Application key: CBE- Cell-based ELISA, FC- Flow cytometry, IC- Immunocytochemistry,
IE- Indirect ELISA, IFC- Indirect flow cytometry, IH- Immunohistochemistry, IP- Immunoprecipitation,
LCI- Live cell imaging, N- Neutralization, WB- Western blot     
Species reactivity key: H- Human, M- Mouse, R- Rat
Control antigen included Lyophilized powder
General information
Anti-Ryanodine Receptor 2 (#ARR-002) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize RyR2 from human, rat, and mouse samples.

Related products for control experiments:
Control peptide antigen (supplied with the antibody free of charge).

Anti-Ryanodine Receptor 2 antibody (#ARR-002) in the literature:
Western blot analysis (WB):
- Rat intrapulmonary artery lysate (1:400) (see Dahan, D. et al. (2012) in Product Citations).

Immunohistochemistry (IH):
- Rat heart sections (1:50) (see Zhu-Mauldin, X. et al. (2012) in Product Citations).
- Rat tibialis anterior muscle sections (1:100) (see Kraner, S.D. et al. (2011) in Product Citations).

Immunocytochemistry (IC):
- Rat adipose-derived stromal cells and rat bone marrow stromal cells (see Forostyak, O. et al. (2016) in Product Citations).
- Mouse primary hippocampal neurons (1:300) (see Gan, K.J. et al. (2015) in Product Citations).

If you know of a relevant citation for this product please let us know.
Scientific Background
Product Citation
Western blot
Anti-Ryanodine_Receptor_2 - Western blot analysis of rat heart membranes:
Western blot analysis of rat heart membranes:
1. Anti-Ryanodine Receptor 2 antibody (#ARR-002), (1:200).
2. Anti-Ryanodine Receptor 2 antibody, preincubated with the control peptide antigen.
Anti-Ryanodine_Receptor_2 - Expression of Ryanodine Receptor 2  in rat cardiac muscle
Expression of Ryanodine Receptor 2  in rat cardiac muscle
Immunohistochemical staining of paraffin-embedded sections of rat myocardium using Anti-Ryanodine Receptor 2 antibody (#ARR-002), (1:50). Staining is specific for cardiomyocytes while smooth muscles cells in the artery walls are negative (red arrows). Hematoxilin is used as the counterstain.
Anti-Ryanodine_Receptor_2 - Expression of Ryanodine Receptor 2 in mouse cerebellum
Expression of Ryanodine Receptor 2 in mouse cerebellum
 Immunohistochemical staining of mouse cerebellum frozen sections with Anti-Ryanodine Receptor 2 antibody (#ARR-002), (1:100), (green fluorescence). A. The highest expression of Ryanodine Receptor 2 is in the molecular layer (Asterisk) but there is also some expression in the soma of Purkinje cells (arrows). B. In the same section, there is staining for parvalbumin (red), a marker for Purkinje cells. C. Merged image of panels A and B demonstrates that Ryanodine Receptor 2 is localized both in the area surrounding the dendritic tree and in the soma of Purkinje cells. DAPI is used as the counterstain (blue).
Mouse primary hippocampal neurons (1:300) (see Gan, K.J. and Silverman, M.A. (2015) Mol. Biol. Cell 26, 1058.)
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For research purposes only, not for human use
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