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Ion Channels >> Cell Signaling Tools >> Protein Phosphatases >> Inhibitors
Certificate of analysis


Tacrolimus, Fujimycin
  • Cat #: F-900
  • Size: 1 mg, 5 x 1 mg, 10 x 0.1 mg
  • Source: Natural
  • MW: 804.03 Da.
OriginIsolated from Streptomyces tsukubaensis.
Chemical name(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
5,6,8,11, 12,13,14,15,16,17,18,19,24,25,26,26a Hexadecahydro-5,19 - dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyc lohexyl]-1- methylethenyl]-14,16-dimethoxy-4,10,12,18-te tramethyl-8-(2-propen-1-yl)- 15,19-epoxy-3H-pyrido[2,1-c ][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Molecular formulaC44H69NO12.
CAS number104987-11-3.
ActivityFK-506 is an immunosuppressant and inhibits calcineurin (PP-2B)1-3.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionDMSO or Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to two weeks at 4°C or six months at -20°C.
Our bioassay
Our bioassay
FK-506 - Alomone Labs FK-506 inhibits the anti-adipogenic effect of calcineurin in 3T3-L1 cells.
Alomone Labs FK-506 inhibits the anti-adipogenic effect of calcineurin in 3T3-L1 cells.
Cells were induce to undergo differentiation with 1 µg/ml insulin for 4 days (A, B and C). The cells were treated for the first 4 days of differentiation with 1 µM Ionomycin (#I-700), (B and C) in the presence of 5 ng/ml (C) or absence (A and B) of FK-506 (#F-900). After 10 days, the cells were stained with Oil red O and visualized with light microscopy.
1. Fruman, D.A. et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 3686.
2. Cardenas, M.E. et al. (1998) Trends Biotechnol. 16, 427.
3. Kino, T. et al. (1987) J. Antibiot. 40, 1249.
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Last update:11/12/2013
For research purposes only, not for human use
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