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Ion Channels >> Ca2+ Signaling >> Voltage-Gated Ca2+ Channels >> Blockers
Certificate of analysis

Flunarizine dihydrochloride

  • Cat #: F-110
  • Size: 1 g, 5 g, 10 g
  • Source: Synthetic
  • MW: 477.4 Da.
  • Target: L-type and T-type Ca2+ channels
Chemical name(E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride.
Molecular formulaC26H26F2N2*2HCl.
CAS number30484-77-6.
ActivityFlunarizine dihydrochloride is a diphenylmethylpiperazine L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat migraine1. Flunarizine dihydrochloride inhibits L- and T-type CaV channels in guinea pig ventricular cells with similar potency and in a use dependent manner2.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionDMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to four weeks at 4°C or three months at -20°C.
Our bioassay
Our bioassay
Flunarizine_dihydrochloride - Alomone Labs Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes.
Alomone Labs Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes.
A. Time course of L-type channel (CaV1.2+α2δ1+β1a) activity before and during applications of 10 and 100 μM Flunarizine dihydrochloride (#F-110) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by the horizontal bars. B. Example of superimposed current traces before and during application of 10 and 100 μM Flunarizine dihydrochloride (taken from the experiment described in A).
1. Todd, P.A. and Benfield, P. (1989) Drugs. 38, 481.
2. Tytgat, J. et al. (1988) Naunyn-Schmiedeberg's Arch.Pharmacol. 337, 690.
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Last update:13/08/2017
For research purposes only, not for human use
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