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Other >> Neural Signaling >> Neurotransmission >> Glutamate Signaling >> Glutamate Receptors >> NMDA Receptors >> Blockers

MPX-004

A Potent and Selective Antagonist of GluN2A NMDA Receptor
  • New
    New
  • Bioassay tested
    Bioassay tested
  • Shipped at room temp.
    Shipped at room temp.
  • Cat #: M-280
  • Size: 5 mg, 10 mg, 25 mg, 50 mg
  • Source: Synthetic
  • MW: 455.91 Da.
  • Target: GluN2A receptors
General information
MPX-004 is a synthetic compound that acts as a potent and selective GluN2A-containing NMDA receptor antagonist with an IC50 value of 79 nM in HEK cells1
                                                                                                                                                 
MPX-004 is a pyrazine-containing antagonist with optimal halogen substituents on the phenylsulfonamide aryl ring. It is used as a pharmacological tool for studying the physiology of NMDA receptors containing the GluN2A subunit1.
 
NMDA receptors are heterotetramers composed by 2 GluN1 obligatory subunits and 2 GluN2 (A-D) or GluN3 (A-B) regulatory subunits. GluN2A is the most abundant subunit in the mammalian CNS. Physiological and genetic evidence show that GluN2A-containing receptors are involved in autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders such as Rett Syndrome1,2.
 
Alomone Labs is pleased to offer MPX-004 (#M-280).
Our Bioassay
Specifications
References
 
Our bioassay
MPX-004 - Alomone Labs MPX-004 inhibits NMDA receptor channels expressed in Xenopus oocytes.
Alomone Labs MPX-004 inhibits NMDA receptor channels expressed in Xenopus oocytes. 
A. Time course of NR1/NR2A currents, elicited by transient stimulations with 200 µM glutamate and 200 µM glycine every 100 sec, while membrane potential was held at -80 mV. 100 nM MPX-004 (#M-280), applied for 7 min (bar), significantly inhibits current amplitude. B. Superimposed current traces from the recording shown in A, upon application of control and of 100 nM MPX-004 (as indicated).
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For research purposes only, not for human use
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