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Ion Channels >> Ligand-Gated Ion Channels >> GABA(A) Receptors >> Antagonists


An Antagonist of GABA(A), Glycine, and 5-HT3 Receptors
Cocculin, Picrotin, Picrotoxinin
  • New
  • Bioassay tested
    Bioassay tested
  • Shipped at room temp.
    Shipped at room temp.
  • Cat #: P-325
  • Size: 500 mg, 1 g, 5 g, 10 g
  • Source: Natural
  • MW: 602.58 Da.
  • Target: GABA(A), Glycine, 5-HT3 receptors
General information

Picrotoxin (PTX) is a plant-derived alkaloid that originally showed to be a noncompetitive antagonist of GABA(A) receptors. Later it was discovered that picrotoxin inhibits other anion-selective ligand-gated anion channels including glycine and 5-hydroxytryptamine type 3 (5-HT3) receptors. Inhibition by picrotoxin is likely in a noncompetitive, use-facilitated manner through binding to the channel pore of the receptor1,2
5-HT3 receptor is a member of the cys-loop superfamily of ligand-gated ion channels (LGICs) that includes nicotinic acetylcholine receptors, GABAA, glycine receptors, glutamate and purinergic receptors1,2.
Alomone Labs is pleased to offer Picrotoxin (#P-325).
Our Bioassay
Our bioassay
Picrotoxin - Alomone Labs Picrotoxin inhibits GABA(A) receptors expressed in Xenopus oocytes.
Alomone Labs Picrotoxin inhibits GABA(A) receptors expressed in Xenopus oocytes.
Representative time course of GABA(A) α1/β2 current, activated by a continuous application (top dotted line) of 0.1 µM γ-aminobutyric acid (#G-110), and inhibited by 10 µM Picrotoxin (#P-325), as indicated (bar), at a holding potential of -60 mV.
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For research purposes only, not for human use
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