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Ion Channels >> Ligand-Gated Ion Channels >> GABA(A) Receptors >> Antagonists

U 93631

An Antagonist of GABA(A) and 5-HT3A Receptors
  • New
    New
  • Bioassay tested
    Bioassay tested
  • Shipped at room temp.
    Shipped at room temp.
  • Cat #: U-120
  • Size: 5 mg, 10 mg, 25 mg, 50 mg
  • Source: Synthetic
  • MW: 299.37 Da.
  • Target: GABA(A), 5-HT3A receptors
General information
U 93631 is a synthetic compound that acts as an antagonist of the gamma-aminobutyric acid type A GABA(A) receptors and of 5-hydroxytryptamine type 3A (5-HT3A) receptors, displaying an IC50 of 50 µM for the serotonin receptor4. The compound accelerates the decay of GABA induced currents through an allosteric manner. The properties of U 93631 are shown to be analogous to those of picrotoxin and both share overlapping binding domains1,2.
 
GABA(A) receptors and 5-HT3 (serotonin-gated) receptor channels are members of the Cys-loop superfamily of ligand-gated ion channels. These receptors are expressed throughout the central and peripheral nervous systems and mediate a variety of important physiological functions. GABA(A) receptors mediate the actions of GABA, a major inhibitory neurotransmitter. 5-HT3 receptors mediate those of serotonin3.
 
Alomone Labs is pleased to offer U 93631 (#U-120).
Our Bioassay
Specifications
References
 
Our bioassay
U_93631 - Alomone Labs U 93631 inhibits GABA(A) receptors expressed in Xenopus oocytes.
Alomone Labs U 93631 inhibits GABA(A) receptors expressed in Xenopus oocytes.
Representative time course of GABA(A) α1/β2 current, activated by a continuous application (top dotted line) of 0.1 µM γ-aminobutyric acid (#G-110), and reversibly inhibited by 2 µM and 10 µM U 93631 (#U-120), as indicated (bar), at a holding potential of -60 mV.
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For research purposes only, not for human use
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