Anti-Kv10.2 (EAG-2)

(Ether-a-go-go potassium channel 2, KCNH5)


Product#:APC-053

Sizes:
50 ml
0.2 ml


KV10.2 is a member of the Ether-a-go-go family of voltage-activated potassium channels.  
The family includes today 8 members: the closely related KV10.1 protein, the KV12 (elk)  
(elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3).  
The eag subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. No specific pharmacological blocker has been described.  
Tissue distribution of KV10.2 expression in rats is restricted to neuronal tissue with greater expression in the cortex and thalamus.  
In humans, KV10.2 mRNA was detected in heart and skeletal muscle in addition to brain. 
The physiological role of KV10.2 is unknown at the moment. 

Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of rat Kv10.2. The Anti-Kv10.2 (EAG-2) antibody (#APC-053) can be used for western blot analysis. It has been designed to recognize Kv10.2 from rat and human samples. The antibody is specific for Kv10.2 and it will not cross-react with Kv10.1.

Host:

Rabbit.

Type:
Polyclonal.

Epitope:
Peptide (C)EDPKGSDSENSVTKNPLRK, corresponding to amino acid residues 842-860 of rat Kv10.2 (accession number Q9EP19).
Putative epitope location:
Intracellular, C-terminus.
Homology:

Human - 18/19 amino acid residues identical.

Specificity:
The antibody is specific for Kv10.2 and it will not cross-react with Kv10.1.

Reactivity Confirmed:
Rat, human.
Applications:
Western Blotting:

 

Western blot analysis of rat brain membranes:  
1. Anti-Kv10.2 (EAG-2) antibody (#APC-053), (1:200).   
2. Anti-Kv10.2 (EAG-2) antibody, preincubated with the control peptide antigen.

References:
1. Ludwig, J. et al. (2000) Mol. Sci. Neurosci. 16, 59.
2. Ju, M. et al. (2002) FEBS Lett. 514, 204.  
For research purposes only, not for human use.