Anti-Kir2.2


Product#:APC-042

Sizes:
50 ml
0.2 ml


Kir2.2 is a member of the inward rectifying K+ channel family.  
The Kir2 subfamily comprises 4 known members: Kir2.1, Kir2.2, Kir2.3 and Kir2.4.  
The Kir2 subfamily members are strong inward rectifiers and are believed to be  
involved in maintaining the resting membrane potential and buffering of extracellular K+.  
The Kir2.2 subunit is expressed in the CNS, kidney and heart where it was found to  
form heteromeric channels with Kir2.1.

Host:
Rabbit.
Epitope:
Peptide (C)EVATDRDGRSPQPEHDFDR, 
corresponding to amino acid residues 391-409 of rat Kir2.2 (Accession P52188).
Putative epitope location:
Intracellular, C-terminal part.
Homology:
Mouse identical or 16/19 residues identical; human 13/19 residues identical.
Reactivity Confirmed:
Rat.
Applications:
Western Blotting:
Rat brain membranes (1:200).
Western blotting of rat kidney (1,3) and brain (2,4) membranes: 
1,2. Anti-Kir2.2 (1:200).   
3,4. Anti-Kir2.2, preincubated with the control peptide antigen.

References:
1. Nichols, C.G. and Lopatin, A.N. (1997) Annu Rev Physiol. 59, 171.
2. Preisig-Muller, R.et al. (2002) PNAS USA 99, 7774.  
For research purposes only, not for human use.