Anti-Kv7.1 (KCNQ1)


Product#:APC-022

Sizes:
50 ml
0.2 ml


Kv7.1 (KCNQ1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5).  
The channel has been intensively studied since it was found that together with MinK (Isk) it  
underlay the cardiac Iks current that controls the duration of the action potential of the human heart.  
Indeed mutations on either Kv7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder  
that causes arrhythmias and sudden death. 
Although Kv7.1 expression and function has been mainly investigated in relation with cardiac function  
the channel is widely distributed in epithelial tissues. There it has been implicated in physiological  
functions such as: regulation of acid secretion in the stomach and Cl- secretion into the colon. 

Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of human Kv7.1. The Anti-Kv7.1 (KCNQ1) antibody (#APC-022) can be used for western blot analysis. It has been designed to recognize Kv7.1 from rat, human and mouse samples.  



Host:

Rabbit.

Type:
Polyclonal.

Epitope:

Peptide (C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human Kv7.1 (Accession number P51787).

Putative epitope location:
Intracellular, C-terminus.
Homology:

Rat, mouse - 14/16 amino acid residues identical.

Specificity:
The antibody is specific for KCNQ1, it does not cross react with other QKT proteins.

Reactivity Confirmed:
Rat.
Applications:
Western Blotting:
 
Western blot analysis of rat heart membranes: 
1. Anti-Kv7.1 (KCNQ1) antibody (#APC-022), (1:200).   
2. Anti-Kv7.1 (KCNQ1) antibody, preincubated with the control peptide antigen

References:
1. Wang, Q. et al. (1996) Nat. Genet. 12, 17.  
2. Grahammer, F. et al. (2001) Gastroenterology 120, 1363.  
3.  Mall, M. et al. (1998) Am. J. Physiol. 275, G1274.  
For research purposes only, not for human use.