Angiotensin II receptor type 1 or AT₁ receptor is one of the receptors that binds the octapeptide hormone Angiotensin II (Ang II).

Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na⁺ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

Most of the physiological actions of Ang II are mediated by AT₁ receptor a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.

The AT₁ receptor is coupled to a G_q/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP₃) and intracellular Ca²⁺ mobilization. In addition to the rapid actions mediated by InsP₃ and Ca²⁺ signaling, AT₁ receptor elicits other signaling responses including activation of the MAPK and Jak/STAT. Together, these signaling pathways mediate most of Ang II cellular responses that include, control of hormone secretion, regulation of cell growth and apoptosis, regulation of ion channels activation and cell migration.

In accordance with the pleiotropic actions of Ang II, the AT₁ receptor has a wide distribution with high levels detected in the adrenal gland, kidney, brain, heart, liver, etc.

As is the case with many other peptide receptors, the AT₁ receptor undergoes ligand-induced endocytosis, a process that contributes to receptor desensitization and sequestration and contributes to regulate receptor signaling.

Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the Angiotensin II Receptor Type-1.  Anti-Angiotensin II Receptor Type-1 (extracellular) antibody can be used in western blot, immunohistochemistry, immunocytochemistry and indirect flow cytometry applications, and will recognize Angiotensin II Receptor Type-1 from rat, mouse and human samples.