Cl– channels are involved in several physiological functions ranging from epithelial fluid regulation to skeletal muscle contractibility. They are also …
Continue readingIon Channels
CRACking STIM and Orai Currents
Changes in the intracellular free Ca2+ concentration [Ca2+] in regulate a large number of physiological processes and have a major …
By Ronit Cherki, Ph.D.
Continue reading ENaC and ASIC Channels at a Glance
The ENaC/degenerin channel superfamily comprises channels that are not voltage-gated but do involve the passage of ions, namely Na+. These …
By Melanie Grably, Ph.D., Scientific Editor, Marketing Division
Continue reading In Focus: Two Pore Segment Channels (TPCs)
Among various vertebrate species, three genes are known to encode two pore segment channels (TPCs) termed TPC1-3. Interestingly, TPC3 seems …
By Alomone Labs
Continue reading In Focus: Connexin and Pannexin Gap Junction Channels
Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells2. …
By Alomone Labs
Continue reading Setting the Pace with NaV1.5 Channels
SCN5A is the gene encoding NaV1.5 voltage-gated Na+ channels. These membrane proteins are responsible for the initiation and propagation of …
By Roei Levy, M.Sc. and Melanie Grably, Ph.D.
Continue reading Ion Channels and Pain
Pain perception becomes a burden and ceases to be physiologically beneficial when the threat causing the pain is gone and …
By Roei Levy, M.Sc. and Melanie Grably, Ph.D.
Continue reading T-Type Ca2+ Channels
T-type Ca2+ channels are at the heart of numerous research topics such as pain and epilepsy. This paper aims at …
By Lilach Chen, M.Sc. and Melanie Grably, Ph.D.
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