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Receptors

Endothelin Receptors

In 1988, a 21-amino acid endothelium-derived bioactive peptide was cloned and named endothelin (ET)1. Later, two other isoforms differing from …

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Muscarinic Receptors

Acetylcholine, the major neurotransmitter in the central and the peripheral nervous system, can act through two kinds of receptors1: ionotropic …

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The Ionotropic GABAA Receptor

GABA (g-aminobutiric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1

The GABA transmitter interacts with two major types of receptors: ionotropic GABAA (GABAAR) and the metabotropic GABAB receptors. The GABAAR belong to the ligand-gated ion channel superfamily.2

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The Purinergic P2X Receptors

ATP has been identified as an excitatory neurotransmitter and neuromodulator during physiological processes. The released ATP activates a class of receptors named purinergic receptors: the metabotropic P2Y receptors and the ionotropic P2X receptors1,2. The P2X receptors belong to the ligand-gated ion channel family and are responsible for fast excitatory neurotransmission and are involved in diseases of the nervous system.

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GABA(A) Receptor Family

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the …

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P2Y Receptor Family

P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among …

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Regulatory Aspects of mGluRs

Metabotropic glutamate receptors (mGluRs) are functionally important for inducing long term potentiation (LTP) and long term depression (LTD). They are …

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