Opioid Receptors


Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors which belong to the superfamily of G-protein coupled receptors. Three “classic” types of opioid receptors have been identified: mu (µ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor. Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic µ, δ, and κ receptors.

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  • Loperamide hydrochloride

    An Antagonist of L-type and T-type CaV Channels, HCN Channels, NMDA Receptors and an Agonist of μ-Opioid Receptors

    Cat # L-100
    Source Synthetic
    MW 513.5
    Target L-type, T-type Ca2+, HCN channels, NMDA, μ-opioid receptors
    • Lyophilized Powder

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