Antagonists

Purinergic (P2X) Receptors

Antagonists

The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP. The structure and function of the P2X receptors, investigated mainly using in vitro models, indicate their involvement in synaptic communication, cell death, and differentiation. Seven mammalian P2X receptor subtypes (P2X1–P2X7) have been identified and cloned. All P2X receptor subtypes share the same structure of intracellular N and C-termini two membrane-spanning domains and a large extracellular loop.

Displaying 1 to 20 (out of 22 products)
  • A-317491 sodium salt hydrate

    A Selective Antagonist of P2X3 and P2X2/3 Receptors

    Cat # A-380
    Source Synthetic
    MW 565.57 (free acid, anhydrous)
    Target P2X3 receptors
  • A-740003

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-420
    Source Synthetic
    MW 474.55
    Target P2X7 receptors
  • A-804598

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-415
    Source Synthetic
    MW 315.37
    Target P2X7 receptors
  • A-839977

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-470
    Source Synthetic
    MW 413.26
    Target P2X7 receptors
  • AACBA hydrochloride

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-410
    Source Synthetic
    MW 438.43
    Target P2X7 receptors
  • AF-353

    A Potent and Selective Antagonist of P2X3 Receptor

    Cat # A-375
    Source Synthetic
    MW 400.21
    Target P2X3 receptors
  • AZ 10606120 dihydrochloride

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-405
    Source Synthetic
    MW 495.49
    Target P2X7 channels
  • AZ11645373

    A Potent and Selective Antagonist of Human P2X7 Receptors

    Cat # A-395
    Source Synthetic
    MW 463.51
    Target P2X7 receptors
  • AZD-9056 hydrochloride

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # A-425
    Source Synthetic
    MW 455.46
    Target P2X7 receptors
  • CAY10593 (VU0155069)

    An Antagonist of P2X7 Receptors and Inhibitor of Phospholipase D1

    Cat # C-385
    Source Synthetic
    MW 462.98
    Target P2X7 receptors, Phospholipase D1 (PLD1)
  • Chelerythrine chloride

    An Inhibitor of Protein Kinase C, SERCA Pump, and P2X7 Receptor

    Cat # C-400
    Source Natural
    MW 383.84
    Target PKC, SERCA pumps, P2X7 receptor
  • Evans Blue tetrasodium salt

    An Antagonist of AMPA/Kainate receptors, P2X Receptors and a Potent Inhibitor of L-Glutamate Uptake

    Cat # E-110
    Source Synthetic
    MW 960.8
    Target AMPA, Kainate, P2X receptors
  • GW 791343 hydrochloride

    A Negative Allosteric Modulator of Human P2X7 Receptors

    Cat # G-115
    Source Synthetic
    MW 483.81
    Target P2X7 receptors
  • HMA

    An Antagonist of Na+/H+ Exchangers, P2X7 receptors and TRPA1, ASIC3 Channels

    Cat # H-130
    Source Synthetic
    MW 311.77
    Target NHE exchangers, TRPA1, ASIC3 channels, P2X7 receptors
  • JNJ-47965567

    A Potent and Selective Antagonist of P2X7 Receptors

    Cat # J-115
    Source Synthetic
    MW 488.65
    Target P2X7 receptors
  • JNJ-54166060

    A Novel Potent and Selective Antagonist of P2X7 Receptors

    Cat # J-125
    Source Synthetic
    MW 438.81
    Target P2X7 receptors
  • KN-62

    An Antagonist of P2X7 Receptors and Inhibitor of CaM kinase II

    Cat # K-120
    Source Synthetic
    MW 721.85
    Target P2X7 receptor, CaM kinase type II
  • RO-3

    A Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors

    Cat # R-190
    Source Synthetic
    MW 302.37
    Target P2X3 receptors
  • Ro-51

    A Highly Potent and Selective Antagonist of P2X3 and P2X2/3 Receptors

    Cat # R-195
    Source Synthetic
    MW 474.29
    Target P2X3 receptors
  • ZINC9315614

    An Antagonist of P2X7 Receptors

    Cat # Z-145
    Source Synthetic
    MW 328.74
    Target P2X7 receptors

* See product page

Displaying 1 to 20 (out of 22 products)