Antibodies

Protease-Activated Receptors

Antibodies

Protease-activated receptors (PARs) belong to the superfamily of G-protein coupled receptors. (PAR-1 – 4) are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This results in the creation of a new N-terminal tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways.

Displaying 1 to 5 products (out of 5 products)
  • Anti-Human PAR1 (extracellular) Antibody

    A Rabbit Polyclonal Antibody to Protease-Activated Receptor-1

    Cat # APR-031
    Type Polyclonal
    Source Rabbit
    Applications ic, ifc, ih, lci, wb, ip*
    Reactivity h
    • Lyophilized Powder
    • Antigen Incl.
    • Shipped at Room Temp.
  • Anti-Human PAR1 (extracellular)-FITC Antibody

    A Rabbit Polyclonal Antibody to Protease-Activated Receptor-1 Conjugated to the Fluorescent dye FITC

    Cat # APR-031-F
    Type Polyclonal
    Source Rabbit
    Applications fc, ic*, lci*
    Reactivity h
    • Lyophilized Powder
    • Antigen Incl.
    • Shipped at Room Temp.
  • Anti-PAR2 Antibody

    A Rabbit Polyclonal Antibody to Protease-Activated Receptor-2

    Cat # APR-032
    Type Polyclonal
    Source Rabbit
    Applications ic, ih, wb, ifc*, ip*
    Reactivity h, m, r
    • Lyophilized Powder
    • Antigen Incl.
    • Shipped at Room Temp.
  • Anti-PAR4 (extracellular) Antibody

    A Rabbit Polyclonal Antibody to Protease-Activated Receptor-4

    Cat # APR-034
    Type Polyclonal
    Source Rabbit
    Applications ic, ifc, ih, lci, wb, ip*
    Reactivity h, m, r
    • Lyophilized Powder
    • Antigen Incl.
    • Shipped at Room Temp.
  • Anti-PAR4 (extracellular)-FITC Antibody

    A Rabbit Polyclonal Antibody to Protease-Activated Receptor-4 Conjugated to the Fluorescent Dye FITC

    Cat # APR-034-F
    Type Polyclonal
    Source Rabbit
    Applications fc
    Reactivity h, m, r
    • Lyophilized Powder
    • Antigen Incl.
    • Shipped at Room Temp.

* See product page

Displaying 1 to 5 products (out of 5 products)