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Blockers

Voltage-Gated Ca2+ Channels

Blockers

Voltage-dependent Ca2+ channels (CaV) form an important route for Ca2+ entry into cells, upon deviations from the cells’ resting membrane potential. There are ten CaV α1 subunit genes, divided into three subfamilies on both a functional and sequence homology basis. The CaV1 subfamily includes four genes which encode the L-type channels, the CaV3 subfamily includes three genes encoding the T-type channels and the CaV2 subfamily consists of three isoforms encoding P/Q- , N- and R-type channels, with all three contributing to neurotransmitter release in neurons.

Displaying 1 to 20 (out of 83 products)

  • Huwentoxin-XVI

    A Potent and Reversible Blocker of CaV2.2 Channels
    Cat # STH-105
    MW 4437 Da.
    Target N-type Ca2+ channels
    More info
    • Bioassay Tested

  • α-Conotoxin PeIA

    An Antagonist of nAChR and N-Type Ca2+ Channels

    Cat # STC-970
    MW 1652 Da.
    Target nAChR, CaV2.2 Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Agatoxin IVA

    A Blocker of P/Q-Type CaV Channels

    Cat # STA-500
    MW 5202 Da.
    Target P-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Agatoxin TK

    A Blocker of P/Q-Type CaV Channels

    Cat # STA-530
    MW 5273 Da.
    Target P-type and Q-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CVIA

    A Blocker of N-Type CaV Channels 

    Cat # STC-750
    MW 2642 Da.
    Target CaV2.2 channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CnVIIA

    A Specific Blocker of N-Type Ca2+ Channels 

    Cat # STC-800
    MW 2848 Da.
    Target N-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CVIB

    A Blocker of N-, P/Q-Type Ca2+ Channels

    Cat # STC-410
    MW 2710 Da.
    Target N-, P/Q-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CVIC

    A Blocker of N-, P/Q-Type Ca2+ Channels

    Cat # STC-420
    MW 2783 Da.
    Target N-, P/Q-type channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CVIE

    A Blocker of N-Type Ca2+ Channels

    Cat # STC-760
    MW 2640 Da.
    Target N-Type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin CVIF

    A Blocker of N-Type CaV Channels 

    Cat # STC-770
    MW 2665 Da.
    Target CaV2.2 channels
    More info
    • Bioassay Tested

  • ω-Conotoxin FVIA

    A Potent Blocker of CaV2.2 Channel

    Cat # STC-780
    MW 2567 Da.
    Target CaV2.2 channels
    More info
    • Bioassay Tested

  • ω-Conotoxin GVIA

    A Blocker of N-Type Ca2+ Channels

    Cat # C-300
    MW 3037 Da.
    Target N-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin MVIIA

    A Specific Blocker of CaV2.2 Channel

    Cat # C-670
    MW 2639.20 Da.
    Target CaV2.2 Ca2+ channel
    More info
    • Bioassay Tested

  • ω-Conotoxin MVIIC

    A Blocker of Presynaptic CaV (N- and P/Q-Type) Channels

    Cat # C-150
    MW 2750 Da.
    Target N-type and P/Q-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin MVIID

    A Blocker of N- and P-Type CaV Channels 

    Cat # STC-751
    MW 2695 Da.
    Target N-, P-type Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin RVIA

    A Blocker of CaV2.2 Ca2+ Channel

    Cat # STC-850
    MW 2915 Da.
    Target CaV2.2 Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin SO3

    A Blocker of N-Type Ca2+ Channels

    Cat # STC-470
    MW 2562 Da.
    Target CaV2.2 Ca2+ channels
    More info
    • Bioassay Tested

  • ω-Conotoxin SVIB

    A Potent Blocker of N-Type CaV Channels

    Cat # STC-160
    MW 2739 Da.
    Target N-Type CaV channels
    More info
    • Bioassay Tested

  • ω-Grammotoxin SIA

    A Novel Blocker of CaV2.1 (P-type) and CaV2.2 (N-type) Channels

    Cat # G-450
    MW 4109.7 Da.
    Target P-type and N-type Ca2+ channels
    More info
    • Bioassay Tested

  • Amitriptyline hydrochloride

    A Blocker of L-Type CaV Channels, an Antagonist of 5-HT2 Serotonin Receptors, and an Agonist of α-Adrenoceptors

    Cat # A-155
    Source Synthetic
    MW 313.86
    Target L-type Ca2+ channels, α-adrenergic receptors, 5-HT2 serotonin receptors
    More info
    • Bioassay Tested

* See product page

Displaying 1 to 20 (out of 83 products)