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L-Type (CaV1) Channels

L-type Ca2+ channels include four different isoforms of the α1 pore-forming subunit: CaV1.1, CaV1.2, CaV1.3 and CaV1.4. Their expression is detected in muscle, heart, retina and neurons where they play important roles in muscle contraction, hormone secretion, neuronal excitability and gene expression.