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NaV1.7 Channels

NaV1.7  (Scn9a) is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain-of-function mutations in the NaV1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities). Loss-of-function mutations in NaV1.7 channels, lead to complete ablation of pain perception in humans. Scn9a is a major therapeutic target for pain.