Immuno-Colocalization Products

Alomone Labs has developed two innovative platforms for studying protein-protein interaction and/or protein co-localization in complex immunostaining or immunoprecipitation protocols:

 

ATTO-Conjugated Antibodies: These antibodies can be used in immunohistochemistry (IHC) and immunocytochemistry (ICC) with same species antibodies.

 

Save time and resources with ONE antibody.

 

Benefits of immunostaining with ATTO-conjugated antibodies:
Direct immuno-fluorescence
Secondary antibodies are not necessary
Ideal for immuno-colocalization with same species/host antibodies

 

Guinea Pig-Raised Antibodies: Antibodies raised in guinea pig can be used with any non-guinea pig second species antibodies (e.g. antibodies raised in mouse, rabbit, goat, etc.) in complex immunostaining or immunoprecipitation protocols. Our line of guinea pig raised antibodies can be combined with any of our rabbit-raised or ATTO-conjugated antibodies in complex immunostaining protocols.

Two-Pore Domain K+ Channels

Two pore domain K+ channel (K2P) family consists of 15 members which are further divided to six subfamilies on the basis of structural and functional properties. All family members are tightly controlled by various chemical and physical stimuli such as pH, oxygen tension, lipids, mechanical stretch, G-protein coupled receptors, transmitters and other endogenous modulators, and are targets for clinically important compounds such as volatile anesthetic. These channels are also known as “leak channels”. This name is given since they are open across the physiological voltage range, show little voltage or time dependence and are believed to underlie many of the K+ leak currents. This leak is active during the rest period of excitable cells, stabilizes membrane potential below firing threshold and hasten repolarization in many neurons including cerebellar granular neurons.