CLC channels are often subdivided based on their subcellular location: channels that are expressed at the plasma membrane (CLC-1, CLC-2, CLC-Ka and CLC-Kb) and channels that are located in intracellular organelles (CLC-3 to CLC-7). Strong evidence suggest that at least CLC-4, CLC-5 and CLC-7 function as Cl^–/H⁺ antiporters, that couple Cl^– influx to H⁺ efflux.