Naᵥ1.7

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

54 Results
  • GsMTx-4-ATTO Fluor-647N
    Bioassay Tested
    GsMTx-4-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 4723 Da
  • ATX-II-ATTO Fluor-647N
    Bioassay Tested
    ATX-II-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of NaV sodium channels
    • Product Code: STA-700-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of NaV sodium channels
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 5561 Da
  • ProTx-II-Biotin
    Bioassay Tested
    ProTx-II-Biotin
    A highly potent gating modifier of NaV1.7 channels with weaker activity on CaV3.2 T-type channels conjugated to biotin
    • Product Code: STP-100-B
    • Short Description: A highly potent gating modifier of NaV1.7 channels with weaker activity on CaV3.2 T-type channels conjugated to biotin
    • Label: Biotin
    • Applications: Electrophysiology, Fluorescence staining, Immunofluorescence, Indirect flow cytometry
    • MW: 4053 Da
  • µ/ω-TRTX-Tap1a
    Bioassay Tested
    µ/ω-TRTX-Tap1a
    A potent blocker/gating-modifier of multiple NaV and T-type (CaV3.1, CaV3.2) channels
    • Product Code: STT-600
    • Short Description: A potent blocker/gating-modifier of multiple NaV and T-type (CaV3.1, CaV3.2) channels
    • Applications: Electrophysiology
    • MW: 4182.7 Da
  • µ-TRTX-Tsp1a
    Bioassay Tested
    µ-TRTX-Tsp1a
    A potent blocker of NaV1.7 channels
    • Product Code: STT-500
    • Short Description: A potent blocker of NaV1.7 channels
    • Applications: Electrophysiology
    • MW: 3391 Da
  • VSTX3
    Bioassay Tested
    VSTX3
    A blocker of NaV1.3, NaV1.7, NaV1.8 Voltage-Gated Na+ channels
    • Product Code: STT-350
    • Short Description: A blocker of NaV1.3, NaV1.7, NaV1.8 Voltage-Gated Na+ channels
    • Applications: Electrophysiology
    • MW: 4171.8 Da
  • GTx1-15
    Bioassay Tested
    GTx1-15
    A blocker of voltage-gated Na+ and T-Type Ca2+ channels
    • Product Code: STT-300
    • Short Description: A blocker of voltage-gated Na+ and T-Type Ca2+ channels
    • Applications: Electrophysiology
    • MW: 4073.8 Da
  • Pterinotoxin-2
    Bioassay Tested
    Pterinotoxin-2
    A blocker of NaV1.7 and NaV1.3 Na+ channels
    • Product Code: STT-150
    • Short Description: A blocker of NaV1.7 and NaV1.3 Na+ channels
    • Applications: Electrophysiology
    • MW: 3639.3 Da
  • Pterinotoxin-1
    Bioassay Tested
    Pterinotoxin-1
    A blocker of NaV1.7, NaV1.8, and NaV1.3 Na+ channels
    • Product Code: STT-100
    • Short Description: A blocker of NaV1.7, NaV1.8, and NaV1.3 Na+ channels
    • Applications: Electrophysiology
    • MW: 3969.5 Da
  • Ectatotoxin-Rm4a
    Bioassay Tested
    Ectatotoxin-Rm4a
    A potent activator/gating modifier of NaV1.6 and NaV1.7 channels
    • Product Code: STR-010
    • Short Description: A potent activator/gating modifier of NaV1.6 and NaV1.7 channels
    • Applications: Electrophysiology
    • MW: 2994.6 Da
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