Featured Papers in 2017

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KCa4.2 (Slick) Channel Regulation by GABA(B) Receptors

Li, P. et al. (2017) eNeuro 4, e0114.

IKNa currents are mainly produced by KCa4.2 (Slick) and KCa4.1 (Slack) channels. Activation of these channels is achieved by intracellular Na+ ions and is coupled to persistent sodium currents (INaP).

Activation of metabotropic GABA(B) receptors was shown to inhibit INaP currents which in turn inhibited IKNa currents generated by Slick channels in mistral cells, localized to the olfactory bulb.

Immunocytochemical staining of dissociated rat olfactory bulbs primary cultures using Anti-KCa4.2 (Slick) antibody (#APC-126) shows that the channel co-localizes with GABA(B) receptors (Figure 1).

The overall out of this regulatory is to enhance the effectiveness of synaptic potentials.



Figure 1. Expression of KCa4.2 (Slick) channel in rat olfactory bulb.Immunocytochemical staining of dissociated rat olfactory bulbs primary cultures using Anti-KCa4.2 (Slick) antibody (#APC-126). A. KCa4.2 staining (green). B. GABA(B) R1 receptor staining (red). C. Merged image.Adapted from Li, P. et al. (2017) eNeuro 4, e0114. with permission of the Society for Neuroscience.

A Potential Role for Kir5.1 Channel in pH Sensitivity in 5-HT Neurons

Puissant, M.M. et al. (2017) Front. Cell. Neurosci. 11, 34.

NaV1.1, NaV1.6 and NaV1.7 Channels in Muscle Spindle Signaling

Carrasco, D.I. et al. (2017) J. Neurophysiol. 117, 1690.

Aquaporin 3 Mediates H2O2 Signaling in Colon

Thiagarajah, J.R. et al. (2017) Proc. Natl. Acad. Sci. U.S.A. 114, 568.