Featured Papers in 2018

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P2X7 and Circadian ATP Release

Svobodova, I. et al. (2018) Front. Pharmacol. 9, 192.

The suprachiasmatic nucleus (SCN) is the circadian rhythm pacemaker in mammals. Astrocytes of the SCN generate a rhythmic ATP release via P2X7 and P2Y receptors. Blocking P2X7 with specific antagonists, inhibited ATP circadian rhythm generation.

Immunohistochemical staining of rat SCN using Anti-P2X7 Receptor Antibody (#APR-004) shows that the receptor is clearly expressed in astrocytes and co-localizes with GFAP, an astrocyte marker (Figure 1).

This work sheds additional light on the many roles P2X7 receptor has under physiological conditions.



Figure 1. Expression of P2X7 in Rat SCN.Immunohistochemical staining of rat brain sections using Anti-P2X7 Receptor Antibody (#APR-004), (1:1000). P2X7 staining (green) in the suprachiasmatic nucleus is extensively detected in astrocytes. GFAP staining (red) is an astrocyte marker. Merged image shows extensive co-localization of P2X7 and GFAP. DAPI (blue) is used as the counterstain. Lower panels are higher magnifications of the upper panels.Adapted from Svobodova, I. et al. (2018) Front. Pharmacol. 9, 192. with permission of Frontiers.

TREK-1 and Glutamate Release in Astrocytes

Woo, D.H. et al. (2018) Front. Cell. Neurosci. 12, 319.

TrkB Signals as a Monomer and not a Dimer from the Plasma Membrane

Zahavi, E.E. et al. (2018) Sci. Signal. 11, eaao4006.

Presynaptic KV3.4 Channel Regulates Nociceptive Glutamatergic Signaling in Spinal Dorsal Horn

Muqeem, T. et al. (2018) J. Neurosci. 38, 3729.

Lipopolysaccharides Activate BK/KCa1.1 Channels in Bladder Umbrella Cells

Lu, M. et al. (2018) Am. J. Physiol. 314, C643.

Blocking TRPV4 as a Means of Maintaining BBB Integrity

Zhao, H. et al. (2018) Front. Mol. Neurosci. 11, 97.

Accumulation of CaV3.2 in Uninjured Sural Nerve – A Role in Peripheral Sensitization & Neuropathic Pain

Chen, W. et al. (2018) Front. Mol. Neurosci. 11, 24.

Piezo1 Mediates Pressure-Induced Pancreatitis

Romac, J.M. et al. (2018) Nat. Commun. 9, 1715.