Featured Papers in 2018

Presynaptic KV3.4 Channel Regulates Nociceptive Glutamatergic Signaling in Spinal Dorsal Horn

Muqeem, T. et al. (2018) J. Neurosci. 38, 3729.

A fundamental step in nociception requires glutamatergic signaling between primary nociceptors and secondary neurons in the spinal dorsal horn.

Presynaptic KV3.4 channel was found to play an important role in transmitting and relaying nociceptive signaling to the glutamatergic pathway. Expression of KV3.4 was demonstrated by immunohistochemical staining of rat cervical spinal cord sections using Anti-KV3.4 Antibody (#APC-019). KV3.4 immunostaining was observed in peptidergic nociceptive fibers with calcitonin gene-related peptide (CGRP), (Figure 1), and with non-peptidergic nociceptive fibers as well as with the presynaptic VGLUT2 marker.

Electrophysiological experiments indicate an important regulatory role for KV3.4 in glutamatergic signaling in nociception. The authors suggest that increasing the activity of KV3.4 in DRGs may represent analgesic effects.

Figure 1. Expression of KV3.4 in rat dorsal horn.Immunohistochemical staining of rat spinal cord sections using Anti-KV3.4 Antibody (#APC-019). KV3.4 staining (green) is observed in dorsal horn laminae I–III. KV3.4 immunoreactivity partially co-localizes with CGRP staining (red).Adapted from Muqeem, T. et al. (2018) J. Neurosci. 38, 3729. with permission of the Society for Neuroscience.

Lipopolysaccharides Activate BK/KCa1.1 Channels in Bladder Umbrella Cells

Lu, M. et al. (2018) Am. J. Physiol. 314, C643.

Blocking TRPV4 as a Means of Maintaining BBB Integrity

Zhao, H. et al. (2018) Front. Mol. Neurosci. 11, 97.

Accumulation of CaV3.2 in Uninjured Sural Nerve – A Role in Peripheral Sensitization & Neuropathic Pain

Chen, W. et al. (2018) Front. Mol. Neurosci. 11, 24.

Piezo1 Mediates Pressure-Induced Pancreatitis

Romac, J.M. et al. (2018) Nat. Commun. 9, 1715.