Featured Papers in 2018

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Is P2X7 Receptor a Therapeutic Target in Diabetes?

Tozzi, M. et al. (2018) Sci. Rep. 8, 8926.

In pancreatic β-cells, ATP is released through exocytosis of insulin granules following glucose stimulation. In this featured paper, Tozzi, M. et al. show that a large fraction of ATP released involves the cooperation between P2X7 receptor and Pannexin-1 gap junction channel. Immunocytochemical staining of rat and mouse INS-1E cells using Anti-P2X7 Receptor Antibody (#APR-004) shows that P2X7 receptor is expressed in clusters (Figure 1). Pharmacological experiments using P2X7 agonists/antagonists were in accordance with ATP release following glucose stimulation. These results strongly suggest the possible role of P2X7 receptor as a therapeutic target in diabetes.



Figure 1. Expression of P2X7 Receptor in Rat and Mouse INS-1E Cells.Immunocytochemical staining of pancreatic INS-1E cells using Anti-P2X7 Receptor Antibody (#APR-004), (green). A. Rat pancreatic cells. B. Mouse pancreatic cells. P2X7 staining in both cell types is shown in clusters. Insulin vesicle staining is shown in red.Adapted from Tozzi, M. et al. (2018) Sci. Rep. 8, 8926. with permission of SPRINGER NATURE.

P2X7 and Circadian ATP Release

Svobodova, I. et al. (2018) Front. Pharmacol. 9, 192.

TREK-1 and Glutamate Release in Astrocytes

Woo, D.H. et al. (2018) Front. Cell. Neurosci. 12, 319.

TrkB Signals as a Monomer and not a Dimer from the Plasma Membrane

Zahavi, E.E. et al. (2018) Sci. Signal. 11, eaao4006.

Presynaptic KV3.4 Channel Regulates Nociceptive Glutamatergic Signaling in Spinal Dorsal Horn

Muqeem, T. et al. (2018) J. Neurosci. 38, 3729.

Lipopolysaccharides Activate BK/KCa1.1 Channels in Bladder Umbrella Cells

Lu, M. et al. (2018) Am. J. Physiol. 314, C643.

Blocking TRPV4 as a Means of Maintaining BBB Integrity

Zhao, H. et al. (2018) Front. Mol. Neurosci. 11, 97.

Accumulation of CaV3.2 in Uninjured Sural Nerve – A Role in Peripheral Sensitization & Neuropathic Pain

Chen, W. et al. (2018) Front. Mol. Neurosci. 11, 24.

Piezo1 Mediates Pressure-Induced Pancreatitis

Romac, J.M. et al. (2018) Nat. Commun. 9, 1715.