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GPCR Pathways

Issue No. 2

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Involvement of Ca2+ in the Apoptotic Process – “Friends or Foes”

Over the past two decades, the ubiquitous position of Ca2+ signaling in cellular apoptosis has been carefully investigated. The body of work described here highlights the complex role played by Ca2+ in generation, regulation and coordination apoptosis. Introduction The word ‘apoptosis’ is …


T Cell Signaling and Activation: No Simple Matter

T cells are central players of the adaptive immune response, which help protect the host against different pathogens ranging from bacteria to fungi and viruses. In order to perform their function, T cells need to be activated, a process that could lead to a variety of responses including …


The Role of Neurotrophin Receptor p75NTR in Cancer

No generalizations about the role of this enigmatic receptor in cancer can be made. As in all other aspects of its biology, the effects of p75NTR remain cell type specific, and their pattern has yet to be discovered. p75 neurotrophin receptor (p75NTR) was the first receptor to be found for the …


K+ Channels and Cancer: Surprising New Discoveries

K+ channels belong to a large class of transmembrane proteins that specifically regulate the transport of K+ ions across biological membranes. Today about 80 different K+ channels have been identified which are expressed in virtually every cell type. K+ channels are involved in a wide variety …


Live or Let Die in Neuroscience: The Story of the Proneurotrophins

Although it has been more than forty years since the neurotrophins were first discovered we are only now starting to appreciate the complexity of their true nature. These compounds lead a fascinating double life: as the proneurotrophin they bind to p75NTR and sortilin to set in motion diverse …


P2Y Receptors: Mediators of Extracellular Nucleotide Actions

The notion that adenine and uridine nucleotides could function as extracellular signaling molecules was met with considerable resistance when it was proposed more than twenty years ago. However, this concept has been widely embraced in the last decade with the identification of two families of …