Over the past two decades, the ubiquitous position of Ca2+ signaling in cellular apoptosis has been carefully investigated. The body …
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T Cell Signaling and Activation: No Simple Matter
T cells are central players of the adaptive immune response, which help protect the host against different pathogens ranging from …
Continue readingThe Role of Neurotrophin Receptor p75NTR in Cancer
No generalizations about the role of this enigmatic receptor in cancer can be made. As in all other aspects of …
Continue readingK+ Channels and Cancer: Surprising New Discoveries
K+ channels belong to a large class of transmembrane proteins that specifically regulate the transport of K+ ions across biological …
Continue readingLive or Let Die in Neuroscience: The Story of the Proneurotrophins
Although it has been more than forty years since the neurotrophins were first discovered we are only now starting to …
Continue readingSomatostatin and the Somatostatin Receptors: Versatile Regulators of Biological Activity
It has been more than thirty years since the discovery of a small tetradecapeptide that was able to inhibit the …
Continue readingP2Y Receptors: Mediators of Extracellular Nucleotide Actions
The notion that adenine and uridine nucleotides could function as extracellular signaling molecules was met with considerable resistance when it …
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