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GPCR Pathways

Issue No. 4

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The Brains on Adenosine Receptors

Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also serves as a ligand for Adenosine receptors, members of the G-protein coupled receptor superfamily and is involved in many physiological processes including regulation of sleep …


Controversial Feelings about Dopamine Receptors

Dopamine (DA) is a neurotransmitter involved in the control of several crucial cerebral and peripheral functions. It plays a role in modulating autonomic and peripheral functions, controls the cardiovascular and renal functions. These actions are mediated through the interaction of DA with specific …


Putting Pressure on the Angiotensin Receptors

Angiotensins are a family of peptides that are critical players in the control of water and electrolyte balance. Angiotensins mediate their actions via several specific G-protein coupled receptors: AT1, AT2 and MAS receptors. Alomone Labs offers a variety of antibodies targeted against these …


To Fight or to Flee from Adrenoceptors

Adrenoceptors are seven transmembrane proteins belonging to the superfamily of G-protein coupled receptors (GPCRs). They respond to the endogenous ligands adrenaline and noradrenaline by inducing a cascade of physiological effects. These receptors have a central role in blood pressure regulation …


In Focus: Chemokine Receptors

Chemokines (CHEMOtactic cytoKINES) are an important subgroup of the inflammatory cytokine family. More than fifty chemokines are expressed in mammalian cells and are characterized by their relatively small size (~70-90 amino acids), by their conserved N-terminus and cysteine motifs. This group of …


In Focus: Bradykinin Receptors

Kinins form a family of small peptides which are endogenously synthesized in response to pathologic processes such as pathogen infection, tissue damage, inflammation as well as allergic reactions. In response to such insults the kallikrein-kinin system is activated, whereby kallikrein, a tissue or …