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GPCR Pathways

Issue No. 5

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Regulatory Aspects of mGluRs

Metabotropic glutamate receptors (mGluRs) are functionally important for inducing long term potentiation (LTP) and long term depression (LTD). They are essential for synaptic transmission, neuronal development, neuroprotection and cognition. Alomone Labs offers antibodies targeting extracellular …


Melanocortin Receptors in the Kidney and Nervous System

The five melanocortin receptors are members of the seven-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Melanocortins, the ligands of the receptors are a group of structurally similar peptides consisting of α-, β- and γ-melanocyte stimulating hormone (α, β, γ-MSH) and …


Cannabinoid Signaling in the Nervous System

Cannabinoids have been used in Eastern medicine for many years as pain relievers. Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two specific cannabinoid receptors: cannabinoid receptor 1 (CB1 Receptor or CB1R) and …


In Focus: Formyl Peptide Receptors

Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein …