Free shipping starts now, no minimum, no coupons required!


Issue No. 18

Go to issue no.

GABA(A) Receptor Family

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the …

Continue reading

Endothelins and Urotensin II

Endothelins (ET-1,2,3) and Urotensin II are peptides that are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate …

Continue reading

The KV7 (KCNQ)

The KV7 family of K+ channels is part of the larger voltage-dependent K+ channels superfamily. In a family that comprises …

Continue reading

Ion Channels and Cancer

During the last few years a pivotal role for ion channels involvement in cancer has emerged. In Modulator #17, we reviewed examples of possible roles and interplay between ion channels and cancer. Recently, a large body of data has accumulated on the participation of K+, Na+, Ca2+, Cl and ligand-gated channels in cancer and apoptosis. To date, there is no broad consensus on the roles ion channels play in cancer. Ion channels are thought to “assist” cancer by affecting a number of pathways, namely, regulation of cell cycle of proliferating cells, perturbation of membrane potential, prevention of apoptosis, adaptation to harsh conditions, altering intracellular Ca2+ balance, and cell shrinkage. Interestingly, there are some examples of the same ion channel participating both in induction of cancer cell proliferation and in

Continue reading

P2Y Receptor Family

P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among …

Continue reading