Modulator

Issue No. 19

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Ion Channels and Epithelial Tissue Function

Epithelial cells form a dynamic barrier that separates different physiological compartments. On one hand they provide a physical barrier that prevents pathological microbes from entering the host and on the other hand they must maintain tissue homeostasis by allowing the regulated transport of …

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Contribution of Ion Channels in Pain Sensation

Many ion channels are located at the nociceptor peripheral terminal, affecting neuron excitability after injury and as a result affecting pain sensation11. Voltage-gated Na+ and Ca2+ channels, TRP, ASIC, ligand-gated ion channels, P2X, NMDA, AMPA and Kainate receptors are some of the ion channels …

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Venom Peptides and their Mimetics as Potential Drugs

Venomous creatures have a sophisticated mechanism for prey capture which includes a vast array of biologically-active compounds, such as enzymes, proteins, peptides and small molecular weight compounds. These substances target an immense number of receptors and membrane proteins with high affinity, …

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The Role of p75NTR in Cancer

No generalizations about the role of this enigmatic receptor in cancer can be made. As in all other aspects of its biology, the effects of p75NTR remain cell type specific, and their pattern has yet to be discovered. p75 neurotrophin receptor (p75NTR) was the first receptor to be found for the …

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KATP Channels: Linking Cell Metabolism to Cell Excitability

ATP-sensitive K+ channels (KATP channels) were described nearly 20 years ago in membrane patches of isolated ventricular myocytes. Since then, channels with similar properties have been described in pancreatic β-cells, skeletal and smooth muscle cells and neurons, where they serve as couplers …

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Interactions of KCNE Auxiliary Subunits with KV and other Channels

KCNEs are integral membrane proteins that associate with and strongly modulate the activity of several ion channels. The different KCNE isoforms are widely and differentially expressed in muscular and neuronal tissues as well as in epithelial cells. Mutations in KCNE genes were shown to lead to …

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