Issue No. 23

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Tripping Over TRPC

The canonical transient receptor potential channels (TRPCs) are non-selective cation channels that are expressed in a variety of multicellular organisms with different functions. The TRPC family can be divided by homology and function into four subfamilies: TRPC1, TRPC2 (a pseudogene in human), …


Ionotrophic ATP (P2X) Receptors

P2X receptors are surface membrane ligand-gated channel proteins that rapidly translate extracellular ATP elevation into an intracellular Ca2+ surge which affects the cell’s secretion, gene expression, contraction and migration capabilities as well as viability and differentiation status. Here, …


Characterization of Neuronal K+ Channels

A wide variety of K+ currents recorded in neurons can be distinguished according to their functional and pharmacological properties. The identification of the channel family and subunits necessitates specific modulators and antibodies. Alomone Labs' contribution to the advances made in K+ channels …


Voltage-Gated Ca2+ Channels in the Cardiovascular System

Voltage-gated Ca2+ channels play a pivotal role in the regulation of a wide range of cellular processes, including membrane excitability, Ca2+ homeostasis, protein phosphorylation, gene regulation, muscle contraction and vesicular secretion. The L-type voltage-gated Ca2+ channels are the most …


α-Latrotoxin: A Potent Inducer of Secretion

α-Latrotoxin is a 130 kD protein toxin that is found in the black widow spider venom and is the only protein in the venom that affects mammals. α-Latrotoxin affects the nervous system of the bitten organism by causing massive transmitter release in many synapses, emptying the signaling reservoir …