Modulator

Issue No. 27

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NaV Channels and Pain

The role of NaV  Channels in several types of pain opens a gateway for the development of specific sodium-channel inhibiting agents for the treatment of chronic pain. In this short piece we demonstrate the use of Alomone Labs NaV-related products in pain research. Right: DRGs play a pivotal role …

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TTA-P2 and TTA-A2: Specific and Potent CaV3 Channel Blockers

Genes encoding T-type CaV channels yield three pore-forming subunits: CaV3.1, CaV3.2 and CaV3.3 which give rise to currents that are pharmacologically and electrophysiologically different from the high voltage CaV1 and CaV2 channel currents. Due to their important physiological roles, and to the …

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NMDA Receptor Dynamics Dictate Neuronal Plasticity and Function

N-Methyl-D-Aspartate  Receptor  (NMDAR)  are  ubiquitously  expressed  along  the  central nervous system and are instrumental to various physiological processes such as synaptic plasticity and learning. Nevertheless, several mental disabilities including schizophrenia and Alzheimer’s …

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In Focus: 5-HT3 Receptors

5-HT (5-hydroxytryptamine, serotonin) is one of the most versatile neurotransmitters. It signals in part through 5-HT3 receptors which belong to the super family of ligand-gated ion channels. 5-hydroxytryptamine type 3 (5-HT3) receptors are cation-selective Cys-loop receptors expressed in the …

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In Focus: Piezo Channels

Mechanical stimulus is the driving force for numerous physiological processes including pain sensation, hearing, and blood pressure regulation2. Piezo1 and Piezo2 were first characterized in a mouse neuroblastoma cell line, where shear force to the cell membrane induced mechanically activated …

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