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µ-Conotoxin BuIIIC

Mu-Conotoxin BuIIIC

A Blocker of NaV1.4 Channel 

Cat #: STC-690
Alternative Name Mu-Conotoxin BuIIIC
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 3006 Da
    Purity: >98% (HPLC)
    Form Lyophilized powder.
    Effective concentration 1 pM - 20 nM.
    Sequence IVDRCCNKGNGKRGCSRWCRDHSRCC.
    Modifications Disulfide bonds between Cys5-Cys19, Cys6-Cys25, and Cys15-Cys26. Cys26 - C-terminal amidation.
    Structure
    Molecular formula C116H189N49O34S6.
    Activity µ-Conotoxin BuIIIC is a selective NaV1.4 blocker1.
    References-Activity
    1. Holford, M. et al. (2009) Toxicon 53, 90.
    Accession number C1J5M7.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs µ-Conotoxin BuIIIC blocks NaV1.4 currents expressed in Xenopus oocytes.
      Alomone Labs µ-Conotoxin BuIIIC blocks NaV1.4 currents expressed in Xenopus oocytes.
      A. Time course of µ-Conotoxin BuIIIC (#STC-690) blocking action on NaV1.4 currents. Peak current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and cells were stimulated by a 100 ms voltage step to -10 mV. 20 nM µ-Conotoxin BuIIIC were perfused as indicated by the bar (green) during 5 min. B. Superimposed examples of NaV1.4 channel current in the absence (control) and presence (green) of 20 nM µ-Conotoxin BuIIIC (taken from the experiment in A).
    References - Scientific background
    1. Holford, M. et al. (2009) Toxicon 53, 90.
    Scientific background μ-conotoxin BuIIIC, is a peptide toxin originally isolated from Conus Bullatus (Bubble cone). It has the characteristic arrangement of six-cysteine residues (-CC-C-C-CC-) and comprises 26 amino acid residues. μ-conotoxin BuIIIC was demonstrated to be a potent irreversible inhibitor of the voltage-gated Na+ channel skeletal muscle subtype NaV1.4, expressed in Xenopus oocytes. 1 μM toxin was shown to block 96% of the channel. The novel structural determinants of BuIIIC along with its ability to potently inhibit NaV1.4 make this conotoxin useful in defining features of the NaV1.4 pharmacophore and thereby facilitate the design of highly subtype-specific ligands that target NaV1.41.
    Target NaV1.4 Na+ channels
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 06/11/2022

    µ-Conotoxin BuIIIC (#STC-690) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use
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