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µ-Conotoxin KIIIA

A Potent Blocker of Mammalian TTX-Sensitive NaV1 Channels

Cat #: C-280
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Synthetic peptide
    MW: 1883 Da
    Purity: >99% (HPLC)
    Effective concentration 0.1-10 μM.
    Sequence CCNCSSKWCRDHSRCC.
    Modifications Disulfide bonds between Cys1-Cys9, Cys2-Cys15 and Cys4 -Cys16. Cys16 - C-terminal amidation.
    Structure
    Molecular formula C70H100N28O22S6.
    Activity μ-Conotoxin KIIIA specifically and in some cases reversibly blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels1.
    References-Activity
    1. Zhang, M.M. et al. (2007) J. Biol. Chem. 282, 30699.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs μ-Conotoxin KIIIA differentially inhibits NaV1.4 and NaV1.2 channels heterologously expressed in Xenopus oocytes.
      Alomone Labs μ-Conotoxin KIIIA differentially inhibits NaV1.4 and NaV1.2 channels heterologously expressed in Xenopus oocytes.
      A. Time course of μ-Conotoxin KIIIA (#C-280) action on NaV1.4 channels. Current amplitudes were plotted as a function of time. Oocyte membrane potential was held at -100 mV and 50 ms ramp to +50 mV was delivered every 10 seconds. 200 nM μ-Conotoxin KIIIA was perfused during the period marked in blue (100 seconds exposure). B. Example traces of NaV1.4 channel currents before (black) and during (blue) μ-Conotoxin KIIIA application. C. Time course of μ-Conotoxin KIIIA action on NaV1.2 channels. 1000 nM μ-Conotoxin KIIIA were perfused during the period marked in green (1000 seconds exposure). D. Example traces of NaV1.2 channel currents before (black) and during (green) μ-Conotoxin KIIIA application. E. Dose-response curves for NaV1.4 and NaV1.2 inhibition (upon 100 seconds exposure to the toxin; such as in A.).
    References - Scientific background
    1. Bulaj, G. et al. (2005) Biochemistry  44, 7259.
    2. Zhang, M.M. et al. (2007) J. Biol. Chem. 282, 30699.
    3. Norton, R.S. (2010) Molecules 15, 2825.
    Scientific background µ-Conotoxin KIIIA is a toxin originally isolated from the venom of Conus Kinoshitai1. µ-Conotoxin KIIIA specifically, and in some cases reversibly, blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels2. In addition, µ-Conotoxin KIIIA was found to act as an effective analgesic in an inflammatory pain assay in mice in vivo2,3.
    Target TTX-sensitive Na+ channels
    Peptide Content: 100%
    Lyophilized Powder
    Last update: 16/11/2022

    µ-Conotoxin KIIIA (#C-280) is a highly pure, synthetic, and biologically active peptide toxin.

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    For research purposes only, not for human use

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