α-Conotoxin AuIA

An Antagonist of α3/β4 nAChR
Cat #: STC-960
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide originated from Conus aulicus (Princely cone).
    MW: 1726 Da.
    Purity: >98% (HPLC)
    Effective concentration 5 -20 µM.
    Sequence GCCSYPPCFATNSDYC.
    Modifications Disulfide bonds between Cys2-Cys8 and Cys3-Cys16. C-terminal Cys16 amidation.
    Molecular formula C72H100N18O24S4.
    Activity α-Conotoxin AuIA is a blocker of α3/β4 nAChR subtypes1.
      • Luo, S. et al. (1998) J. Neurosci. 18, 8571.

    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • Alomone Labs α-Conotoxin AuIA inhibits α3/β4 nAChR channels heterologously expressed in Xenopus oocytes.
        Trace of α3/β4 nAChR channel current in the absence and presence of α-Conotoxin AuIA (#STC-960). Current amplitudes were plotted as a function of time. Membrane potential was held at -80 mV and oocytes were stimulated by exposure to 1 μM ACh (top bar). α3/β4 nAChR currents are inhibited by 2 min application of 20 µM α-Conotoxin-AuIA (green, bottom bar).
      • Janes, R.W. et al. (2005) Curr. Opin. Pharmacol. 5, 280.
      • Luo, S. et al. (1998) J. Neurosci. 18, 8571.
      • Small peptide toxins of Conus origin are highly useful tools for exploring ligand nicotinic acetylcholine receptors (nAChRs) interactions1. There are three α-conotoxin AuIs found in Conus aulicus: AuIA, AuIB and AuIC. α-Conotoxin AuIA is a 16 amino acid peptidyl toxin, belonging to neuronal α 4/7 subfamily of α-conotoxins. This toxin inhibits mammalian neuronal α3/β4 nicotinic acetylcholine receptor channels expressed in Xenopus oocytes. At relatively low concentrations (0.3 and 1.0 μM), this conotoxin is selective and inhibits only α3/β4 subtypes2.
    Target α3/β4 nAChR
    Net Peptide Content: 100%
    Last update: 30/06/2019

    α-Conotoxin AuIA (#STC-960) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use