This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Luo, S. et al. (1998) J. Neurosci. 18, 8571.
Alomone Labs α-Conotoxin AuIA inhibits α3/β4 nAChR channels heterologously expressed in Xenopus oocytes.Trace of α3/β4 nAChR channel current in the absence and presence of α-Conotoxin AuIA (#STC-960). Current amplitudes were plotted as a function of time. Membrane potential was held at -80 mV and oocytes were stimulated by exposure to 1 μM ACh (top bar). α3/β4 nAChR currents are inhibited by 2 min application of 20 µM α-Conotoxin-AuIA (green, bottom bar).
Small peptide toxins of Conus origin are highly useful tools for exploring ligand nicotinic acetylcholine receptors (nAChRs) interactions1. There are three α-conotoxin AuIs found in Conus aulicus: AuIA, AuIB and AuIC. α-Conotoxin AuIA is a 16 amino acid peptidyl toxin, belonging to neuronal α 4/7 subfamily of α-conotoxins. This toxin inhibits mammalian neuronal α3/β4 nicotinic acetylcholine receptor channels expressed in Xenopus oocytes. At relatively low concentrations (0.3 and 1.0 μM), this conotoxin is selective and inhibits only α3/β4 subtypes2.
α-Conotoxin AuIA (#STC-960) is a highly pure, synthetic, and biologically active peptide toxin.
- α-Conotoxin AuIB (#STC-310)
- Anti-Nicotinic Acetylcholine Receptor α3 (CHRNA3) (extracellular) Antibody (#ANC-003)
- Anti-Nicotinic Acetylcholine Receptor β4 (CHRNB4) (extracellular) Antibody (#ANC-014)
- α-Bungarotoxin (#B-100)
- α-Conotoxin ImI (#C-290)
- nAChR Antibody Explorer Kit (#AK-203)
- nAChR Modulator Explorer Kit (#EK-202)
- nAChR Antagonist Explorer Kit (#EK-205)