α-Pompilidotoxin

α-PMTX
An Enhancer of NaV Currents
    Cat #: P-170
    Alternative Name α-PMTX
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1529 Da.
    Purity: >98% (HPLC)
    Effective concentration 10-100 µM.
    Sequence RIKIGLFDQLSKL.
    Modifications Lys13 - C-terminal amidation.
      • α-Pompilidotoxin
    Molecular formula C71H123N19O18.
    Activity α-Pompilidotoxin slows NaV channel inactivation without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3.
      • Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
      • Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
      • Konno, K. et al. (1998) Biochem. Biophys. Res. Commun250, 612.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
      • α-Pompilidotoxin
        Alomone Labs α-Pompilidotoxin enhances native Nacurrents in ND7-23 cells.
        The effect on inward currents of a bath application of 100 µM α-Pompilidotoxin (#P-170) (cyan). NaV currents were elicited every 15 sec from a holding potential of -100 mV, by 20 ms test pulses to -10 mV.
    References - Scientific background
    • 1. Sahara, Y. et al. (2000) Eur. J. Neurosci12, 1961.
    • 2. Konno, K. et al. (2000) Neurosci. Lett285, 29.
    • 3. Konno, K. et al. (1998) Biochem Biophys. Res. Commun250, 612.
    • 4. Harsch, A. et al. (1998) Neurosci. Lett252, 49.
      • α-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. α-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.

        Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 Effective at concentrations of 10 nM in cultured rat cortical neurons.4

    Target TTX-sensitive Nachannels
    Net Peptide Content: 100%
    Last update: 20/08/2019

    α-Pompilidotoxin (#P-170) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use