β-Pompilidotoxin

β-PMTX
An Enhancer of NaV Currents
    Cat #: P-180
    Alternative Name β-PMTX
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1559 Da.
    Purity: >98% (HPLC)
    Effective concentration 10-100 µM.
    Sequence RIKIGLFDQLSRL.
    Modifications Lys13 - C-terminal amidation.
      • β-Pompilidotoxin
    Molecular formula C71H124N22O17.
    CAS No.: 216064-36-7.
    Activity β-Pompilidotoxin slows NaV channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3. β-Pompilidotoxin is five times more potent than α-Pompilidotoxin1,2.
      • Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
      • Konno, K. et al. (2000) NeurosciLett285, 29.
      • Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
      • β-Pompilidotoxin
        Alomone Labs β-Pompilidotoxin enhances native NaV currents in ND7-23 cells.
        The effect on inward currents of a bath application of 100 µM β-Pompilidotoxin (#P-180) (cyan). NaV currents were elicited every 15 sec from a holding potential of -100 mV, by 20 ms test pulses to -10 mV.
    References - Scientific background
    • 1. Sahara, Y. et al. (2000) Eur. J. Neurosci12, 1961.
    • 2. Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
    • 3. Konno, K. et al. (1998) Biochem. Biophys.Res. Commun250, 612.
      • β-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide.

        β-PMTX is a homologous peptide to α-PMTX (position 12 is Arginine instead of Lysine). β-PMTX induces repetitive action potentials and facilitates both excitatory and inhibitory synaptic transmission.

        Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 β-PMTX is five times more potent than α-PMTX.1,2

    Target TTX-sensitive Na+ channels
    Net Peptide Content: 100%
    Last update: 20/08/2019

    β-Pompilidotoxin (#P-180) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use