β-Pompilidotoxin

β-PMTX
An Enhancer of NaV Currents
    Cat #: P-180
    Alternative Name β-PMTX
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1559 Da.
    Purity: >98% (HPLC)
    Effective concentration 10-100 µM.
    Sequence RIKIGLFDQLSRL.
    Modifications Lys13 - C-terminal amidation.
    Structure
    • β-Pompilidotoxin
    Molecular formula C71H124N22O17.
    CAS No.: 216064-36-7.
    Activity β-Pompilidotoxin slows NaV channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3. β-Pompilidotoxin is five times more potent than α-Pompilidotoxin1,2.
    References-Activity
    1. Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
    2. Konno, K. et al. (2000) NeurosciLett285, 29.
    3. Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • β-Pompilidotoxin
      Alomone Labs β-Pompilidotoxin enhances native NaV currents in ND7-23 cells.
      The effect on inward currents of a bath application of 100 µM β-Pompilidotoxin (#P-180) (cyan). NaV currents were elicited every 15 sec from a holding potential of -100 mV, by 20 ms test pulses to -10 mV.
    References - Scientific background
    1. Sahara, Y. et al. (2000) Eur. J. Neurosci12, 1961.
    2. Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
    3. Konno, K. et al. (1998) Biochem. Biophys.Res. Commun250, 612.
    Scientific background

    β-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide.

    β-PMTX is a homologous peptide to α-PMTX (position 12 is Arginine instead of Lysine). β-PMTX induces repetitive action potentials and facilitates both excitatory and inhibitory synaptic transmission.

    Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 β-PMTX is five times more potent than α-PMTX.1,2

    Target TTX-sensitive Na+ channels
    Net Peptide Content: 100%
    Last update: 24/01/2020

    β-Pompilidotoxin (#P-180) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

    Citations

    Citations
    Product citations
    1. Gilchrist, J. et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110, E5016.
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