ω-Conotoxin CVIC

A Blocker of N-, P/Q-Type Ca2+ Channels
Cat #: STC-420
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Conus catus (Cat cone).
    Source Synthetic peptide
    MW: 2783 Da.
    Purity: >99% (HPLC)
    Effective concentration 10-50 nM.
    Sequence CKGKGQSCSKLMYDCCTGSCSRRGKC.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys26. Ile26 – C-terminal amidation.
    Molecular formula C107H180N38O35S7.
    Activity ω-Conotoxin CVIC is a blocker of N-, P/Q-type CaV channels1.
      • Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.

    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • Alomone Labs ω-Conotoxin CVIC inhibits CaV2.2 channels expressed in Xenopus oocytes.
        A. Time course of ω-Conotoxin CVIC (#STC-420) action on CaV2.2 maximum current amplitude. Current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV in 2 mM Ba2+. 50 nM ω-Conotoxin CVIC were perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 50 nM ω-Conotoxin CVIC (taken from the experiment in A).
      • Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.
      • ω-Conotoxin CVIC is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage-gated N-,P- and Q-type CaV channels. CVIC has an effective concentration of 10-50 nM with an IC50 of 7.6 nM for N-type channels and 31 nM for P- and Q-type channels. Compared to other ω-conotoxins, CVIC is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIC’s mRNA transcript thus suggesting that this ω-conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family1.
    Target N-, P/Q-type channels
    Net Peptide Content: 100%
    Last update: 13/03/2019

    ω-Conotoxin CVIC (#STC-420) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use