ω-Conotoxin MVIID

SNX-238
A Blocker of N- and P-Type CaV Channels 
    Cat #: STC-751
    Alternative Name SNX-238
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2695 Da.
    Purity: >98% (HPLC)
    Effective concentration 200 nM - 1 µM.
    Sequence CQGRGASCRKTMYNCCSGSCNRGRC.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25. Cys25 - C-terminal amidation.
      • ω-Conotoxin MVIID
    Molecular formula C99H164N42O33S7.
    Activity ω-Conotoxin MVIID is a voltage-gated N-type Ca2+ channel blocker1.
      • Monje, V.D. et al. (1993) Neuropharmacology 32, 1141.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • ω-Conotoxin MVIID
        Alomone Labs ω-Conotoxin MVIID blocks CaV2.2 channels heterologously expressed in Xenopus oocytes.
        A. Time course of ω-Conotoxin MVIID (#STC-751) action on CaV2.2 maximum currents. Membrane potential was held at -100 mV and cells were stimulated by a 100 ms voltage ramp to +40 mV in the presence of 2 mM Ba2+. 0.2 µM (green) and 1 µM (red) ω-Conotoxin MVIID were perfused as indicated by the bar, each for 200s. B. Superimposed example traces of CaV2.2 channel current in the absence (control) and presence of 0.2 µM (red) and 1 µM (green) ω-Conotoxin MVIID (taken from the experiment in A).
    References - Scientific background
    • 1. Haack, J.A. et al. (1993) Neuropharmacology 32, 1151.
    • 2. Tabata, T. et al. (1995) Neuropharmacology 35, 633.
    • 3. Gandia, L. et al. (1997) Pflugers Arch 435, 55.
    • 4. Monje, V.D. et al. (1993) Neuropharmacology 32, 1141.
      • ω-conotoxins are small, disulfide-rich peptides from the venoms of predatory cone snails that inhibit neuronal voltage-gated Ca2+ channels involved in neurotransmitter release. ω-conotoxin-MVIID (ω-CTx-MVIID) was identified by sequence homology from Conus magus (Magician's cone snail) cDNA library1,4. ω-CTx-MVIID blocks Ca2+ current activated in whole-cell patch-clamp recordings from central neurons of goldfish2. ω-conotoxin MVIID exhibits greater discrimination against the N-channel subtype than any other ω-conotoxin variant to date. ω-conotoxin MVIID has effects on “P-like” subtypes of Ca2+ channels. Furthermore, ω-CTx-MVIID inhibits synaptosomal voltage-sensitive Ca2+ uptake3.
    Target N-, P-type Ca2+ channels
    Net Peptide Content: 100%
    Last update: 20/08/2019

    ω-Conotoxin MVIID (#STC-751) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use