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ω-Conotoxin RVIA

A Blocker of CaV2.2 Ca2+ Channel

Cat #: STC-850
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2915 Da
    Purity: >98% (HPLC)
    Effective concentration 1-5 µM.
    Sequence CKPXGSXCRVSSYNCCSSCKSYNKKCG.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys19, Cys15-Cys26. X = Hydroxyproline.
    Structure
    Molecular formula C116H184N36O40S6.
    Activity CaV2.2 channel blocker1.
    References-Activity
    1. Abbott, J.R. and  Litzinger M.J. (1994) Int. J. Devl. Neuroscience 12, 43.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs ω-Conotoxin RVIA inhibits CaV2.2 channels expressed in Xenopus oocytes.
      Alomone Labs ω-Conotoxin RVIA inhibits CaV2.2 channels expressed in Xenopus oocytes.
      A. Representative time course of ω-Conotoxin RVIA (#STC-850) inhibition of CaV2.2 maximum current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage ramp to +60 mV every 10 sec, and was significantly inhibited by application of 0.5 µM ω-Conotoxin RVIA (top horizontal bar). B. Superimposed traces of CaV2.2 current after the application of control and 0.5 µM ω-Conotoxin RVIA (as indicated). Taken from experiment in A.
    References - Scientific background
    1. Olivera, B.M. et al. (1994) Annu. Rev. Biochem. 63, 823.
    2. Abbott, J.R. and  Litzinger M.J. (1994) Int. J. Devl. Neuroscience 12, 43.
    Scientific background

    ω-Conotoxin RVIA is a 27 amino acid peptidyl toxin, originally isolated from the Conus radiatus (Rayed cone)1 venom and is a synthetic version of the peptide.

    This peptide acts at presynaptic membranes by binding and blocking voltage-gated Ca2+ channels (CaV2.2)2.

    Target CaV2.2 Ca2+ channels
    Peptide Content: 100%
    Last update: 29/08/2021

    ω-Conotoxin RVIA (#STC-850) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

    Shipping and Ordering information