ω-Conotoxin SO3

SO3
A Blocker of N-Type Ca2+ Channels
    Cat #: STC-470
    Alternative Name SO3
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2562 Da.
    Purity: >98% (HPLC)
    Form Lyophilized powder.
    Effective concentration 20-500 nM.
    Sequence CKAAGKPCSRIAYNCCTGSCRSGKC.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25. Cys25 - C-terminal amidation.
    Structure
    • ω-Conotoxin SO3
    Molecular formula C100H165N35O32S6.
    Activity ω-Conotoxin SO3 is a selective N-type Ca2+ channel inhibitor1.
    References-Activity
    1. Wen, L. et al. (2005) Br. J. Pharmacol. 145, 728.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
    Our bioassay
    • ω-Conotoxin SO3
      Alomone Labs ω-Conotoxin SO3 inhibits CaV2.2 channels heterologously expressed in Xenopus oocytes.
      A. Time course of ω-Conotoxin SO3 (#STC-470) blocking action on CaV2.2 currents (α1B + α2δ1 + β1). Maximum current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and cells were stimulated in the presence of 2 mM Ba2+ by a 100 ms voltage ramp to +60 mV. 50 nM ω-Conotoxin SO3 were perfused as indicated by the bar (green) during 150 s. B. Superimposed examples of CaV2.2 channel current in the absence (control) and presence (green) of 50 nM ω-Conotoxin SO3 (taken from the experiment in A).
    References - Scientific background
    1. Li, Z. et al. (2003) Brain Res. 7, 155.
    Scientific background ω-conotoxin SO-3 is a peptide toxin originally isolated from the venom of Conus striatus. It is a selective blocker of N-type CaV channels. SO-3 inhibits INa and IK with IC50 values of 0.49 and 1.6 mM respectively. ω-conotoxin SO-3 does not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration and has no effect on NaV currents, delayed rectifier K+ currents and transient outward K+ currents. ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally1.
    Target CaV2.2 Ca2+ channels
    Net Peptide Content: 100%
    Last update: 24/01/2020

    ω-Conotoxin SO3 (#STC-470) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use
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