ω-Conotoxin SO3

SO3
A Blocker of N-Type Ca2+ Channels
    Cat #: STC-470
    Alternative Name SO3
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 2562 Da.
    Purity: >98% (HPLC)
    Form Lyophilized powder.
    Effective concentration 20-500 nM.
    Sequence CKAAGKPCSRIAYNCCTGSCRSGKC.
    Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25. Cys25 - C-terminal amidation.
      • ω-Conotoxin SO3
    Molecular formula C100H165N35O32S6.
    Activity ω-Conotoxin SO3 is a selective N-type Ca2+ channel inhibitor1.
      • Wen, L. et al. (2005) Br. J. Pharmacol. 145, 728.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or three months at -20°C.
      • ω-Conotoxin SO3
        Alomone Labs ω-Conotoxin SO3 inhibits CaV2.2 channels heterologously expressed in Xenopus oocytes.
        A. Time course of ω-Conotoxin SO3 (#STC-470) blocking action on CaV2.2 currents (α1B + α2δ1 + β1). Maximum current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and cells were stimulated in the presence of 2 mM Ba2+ by a 100 ms voltage ramp to +60 mV. 50 nM ω-Conotoxin SO3 were perfused as indicated by the bar (green) during 150 s. B. Superimposed examples of CaV2.2 channel current in the absence (control) and presence (green) of 50 nM ω-Conotoxin SO3 (taken from the experiment in A).
    References - Scientific background
    • 1. Li, Z. et al. (2003) Brain Res. 7, 155.
      • ω-conotoxin SO-3 is a peptide toxin originally isolated from the venom of Conus striatus. It is a selective blocker of N-type CaV channels. SO-3 inhibits INa and IK with IC50 values of 0.49 and 1.6 mM respectively. ω-conotoxin SO-3 does not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration and has no effect on NaV currents, delayed rectifier K+ currents and transient outward K+ currents. ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally1.
    Target CaV2.2 Ca2+ channels
    Net Peptide Content: 100%
    Last update: 20/08/2019

    ω-Conotoxin SO3 (#STC-470) is a highly pure, synthetic, and biologically active peptide toxin.

    For research purposes only, not for human use