Every lot is tried & tested in a relevant biological assay.
- Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
- Alomone Labs 3-AQC blocks 5-HT3A channels expressed in HEK 293T cells.Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. 3-AQC (#A-205) was applied 30 seconds before stimulation at 10 and 100 µM, as indicated, and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.
3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.
3-AQC (#A-205) is a highly pure, synthetic, and biologically active compound.