This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Alomone Labs Agitoxin-1 blocks KV1.3 channels expressed in Xenopus oocytes.A. Representative time course of Agitoxin-1 (#STA-150) inhibition of KV1.3 current. Membrane potential was held at -100 mV. Current elicited by a 100 ms voltage ramp to +60 mV every 10 sec was significantly and reversibly inhibited by 2 min applications of 0.5 nM and 5 nM Agitoxin-1, as indicated. B. Superimposed traces of KV1.3 current before and after application of 0.5 nM and 5 nM Agitoxin-1, taken from the recording in A.
- 1. Garcia, M.L. et al. (1994) Biochemistry 33, 6834.
Like Agitoxin-2, Agitoxin-1 is a potent blocker of the Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.1
Agitoxin-1 (#STA-150) is a highly pure, synthetic, and biologically active peptide toxin.