Angiotensin A (1-8)

A Potent Agonist of Angiotensin II Receptors  
    Cat #: SPA-105
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1002 Da.
    Purity: ≥98% (HPLC)
    Effective concentration 0.5-1 nM.
    Sequence ARVYIHPF.
      • Angiotensin A (1-8)
    Molecular formula C49H71N13O10.
    CAS No.: 51833-76-2.
    Activity An Angiotensin II Type 1 and Type 2 Receptor Agonist1.
      • Coutinho, D.C. et al. (2013) J. Renin Angiotensin Aldosterone Syst. 15, 480.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Angiotensin A (1-8)
        Alomone Labs Angiotensin A (1-8) activates AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
        Ca2+ response was detected by measuring aequorin-derived fluorescence following application of Angiotensin A )1-8) (#SPA-105) or Angiotensin II (#GPA-100) at different concentrations.
    References - Scientific background
    • 1. Coutinho, D.C. et al. (2013) J. Renin Angiotensin Aldosterone Syst. 15, 480.
    • 2. Brasch, H. et al. (1993) Hypertension 22, 699.
      • Angiotensin A (1-8) is an angiotensin II derivative, a vasoconstrictor peptide of the renin–angiotensin system (RAS) that acts as an angiotensin receptor type 1 and 2 (AT1R and AT2R) agonist.

        This peptide was first discovered in the human plasma and the sole difference between Ang A and Ang II is Ala1 residue instead of Asp1. Ang A is synthesized by enzymatic decarboxylation of Asp1 of the Ang II sequence1.

        Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues. It's a natural hormone which the body produces in order to maintain normal regulation of cardiovascular function.

        Ang II is a primary effector peptide of the RAS in a variety of tissues and is a major target for blood pressure lowering drugs2.

        Studies show that Ang A has the ability to elicit pressor and renal vasoconstrictor responses in normotensive and hypertensive rats. In isolated perfused rat kidney, the peptide causes a vasoconstrictive effect dependent on AT1 receptors1.

    Target Angiotensin receptors
    Net Peptide Content: 100%
    Last update: 01/07/2019

    Angiotensin A (1-8) (#SPA-105) is a highly pure, synthetic, and biologically active peptide.

    For research purposes only, not for human use