Angiotensin II Receptor Pharmacology Explorer Kit

A Screening Package of Angiotensin II Receptor Pharmacology Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-405
Last update: 24/01/2020

Angiotensin II Receptor Pharmacology Explorer Kit (#EK-405) contains Angiotensin Receptors Type I and II agonists and antagonists, ideal for screening purposes.

For research purposes only, not for human use


Product NameCat #Size
Angiotensin A (1-8)
SPA-105 1 x 5 mg
[D-Ala7]-Angiotensin I/II (1-7)
SPA-160 1 x 1 mg
Angiotensin II acetate
SPA-165 1 x 5 mg
A-245 1 x 10 mg
Candesartan cilexetil
C-265 1 x 250 mg
EMD 66684
E-160 1 x 5 mg
Eprosartan mesylate
E-145 1 x 50 mg
Losartan potassium
L-185 1 x 500 mg
SPA-125 1 x 1 mg
PD 123319 ditrifluoroacetate
P-245 1 x 5 mg

Scientific Background

    • Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.

      Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.

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