- Sutko, J.L. et al. (1997) Pharmacol. Rev. 49, 53.
Ryanodine (#R-500) is a natural alkaloid isolated from the stem and roots of Ryania Speciosa, a shrub that grows in tropical locations in Central and South America. Ryanodine is a modulator of intracellular Ca2+ release channels1.
Ryanodine was found to be a potent paralysis inducer of skeletal and cardiac muscles2 by inhibiting the SR Ca2+ release through direct binding with the high affinity Ryanodine receptor (RyR) Ca2+ channel as a tetrameric complex2,3.
Anhydroryanodine is an anhydrous non-active form of ryanodine obtained by dehydration of ryanodine4. Anhydroryanodine can be used as a negative control for ryanodine activity4.
Anhydroryanodine (#A-510) is a highly pure, natural, and biologically active compound.