This product is freeze dried. All water molecules have been removed.
This antibody is shipped with its antigen FREE of charge!
- Peptide CDYENHFNTSKGGEL, corresponding to amino acid residues 401-415 of rat CLCN5 (Accession P51796). Extracellular.
- Rat kidney lysate (1:200).
- Western blot analysis of rat kidney lysate:1. Anti-CLC-5 Antibody (#ACL-003), (1:200).
2. Anti-CLC-5 Antibody, preincubated with the control peptide antigen.
- Rat kidney sections.
CLC5 is a member of the voltage-dependent Cl- channel family that includes nine known members. Based on sequence similarity, CLC5 is closely linked to the CLC3 and CLC4 subunits.
CLC-5 is mainly found in intracellular vesicles, particularly in early endosomes, where it is believed to contribute to their acidification.
The channel is mainly expressed in the kidney, although it has also been found in the small intestine, brain and liver.
Mutations in the CLC5 gene cause Dent's disease, an X-linked renal disorder.