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- Peptide (C)EWNPDLPHTAAKKEK corresponding to amino acid residues 301-315 of rat PACSIN1 (Accession Q9Z0W5). Intracellular.
- Rat and mouse brain lysates (1:200) and human brain neuroblastoma SH-SY5Y cell lysate (1:600).
- Western blot analysis of rat brain (lanes 1 and 3), mouse brain (lanes 2 and 4), (1:200) and human brain neuroblastoma SH-SY5Y cell line lysates (lanes 5 and 6), (1:600):1, 2, 5. Anti-PACSIN1 Antibody (#AIP-023).
3, 4, 6. Anti-PACSIN1 Antibody, preincubated with the negative control antigen.
The protein kinase C and casein kinase substrate in neurons (PACSIN), also known as syndapin, is an F-BAR (elongated BAR) and SH3 (src homology-3) domain-containing protein that is capable of remodeling the plasma membrane and mediating protein-protein interactions.
Three different PACSIN variants are identified, which are differentially expressed: PACSIN I is the neuronal‐specific isoform, PACSIN II is ubiquitously expressed and PACSIN III is expressed mainly in skeletal muscles and heart1.
PACSINs interact with the large GTPase dynamin and several other proteins implicated in vesicle trafficking, PACSIN-dynamin complexes play an important role in vesicle fission at different donor membranes, including the plasma membrane (endocytosis) and Golgi membranes. In addition, PACSINs are implicated in later steps of vesicle cycling in neuronal and non-neuronal cells. PACSINs also engage in additional interactions with molecules involved in several signal transduction pathways, producing crosstalk at the interface between membrane trafficking and the cytoskeleton. Given the distinct expression patterns of the different PACSINs and their splice forms, these proteins could have isoform-specific functions2.